Tsc1 antibody

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August undefined, 2024

WebAntibody-bead conjugates were prepared by adding 2 µg of TSC1 monoclonal antibody ( Product # 37-0400) with 30 µL of protein G-Sepharose beads and rocked overnight at 4°C. … WebMar 21, 2024 · In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, 28215400, 35772404).Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity …

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex

WebJan 12, 2024 · CD11c Cre Tsc1 f/f mice were crossed with Raptor f/f mice to generate CD11c Cre Tsc1 f/f Raptor f/+ mice. Antibodies and reagents. The following antibodies for flow cytometry were from BD ... WebLearn more about Anti-TSC1 Rabbit Polyclonal Antibody (PE (Phycoerythrin)). We enable science by offering product choice, services, process excellence and our people make it happen. novant health pre screen

Hamartin/TSC1 antibody (29906-1-AP) Proteintech

WebThis TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S505 of human TSC1. … WebThis is supported by experiments showing overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth. A shorter 40 kDa isoform of TSC1 has been shown to exist but its function is unknown. Application Note. Anti-TSC1 Antibody has been tested for use in ELISA and Western ... WebAnti-TSC1 antibodies are offered by a number of suppliers. This target gene encodes the protein 'TSC complex subunit 1' in humans and may also be known as Hamartin, LAM, truncated hemartin, and tuberous sclerosis 1 protein. Structurally, the protein is reported to be 129.8 kilodaltons in mass. Based on gene name, fly, ... how to smoke a tri tip on electric smoker

Falguni Parikh - Clinical Scientist - Merck LinkedIn

TSC1 Antibodies - Novus Biologicals

WebDr. Constantinos Demetriades is a Molecular Cell Biologist and a European Research Council (ERC) Grantee. Currently, he holds a Max Planck Research Group Leader position (Associate Professor level) at the Max Planck Institute for Biology of Ageing (MPI-AGE) in Cologne. His work focuses on the intricate molecular and cellular mechanisms of nutrient sensing and … WebFeb 4, 2024 · Tuberous sclerosis complex subunit 1 (TSC1) and 2 (TSC2) are frequently mutated in non–small cell lung cancer (NSCLC), however, their effects on antitumor immunity remained unexplored.A CRISPR screening in murine Kras G12D /Trp53 −/− (KP) model identified Tsc1 and Tsc2 as potent regulators of programmed cell death ligand 1 … how to smoke a turkey breast videoWebMar 21, 2024 · TSC1 (TSC Complex Subunit 1) is a Protein Coding gene. Diseases associated with TSC1 include Tuberous Sclerosis 1 and Lymphangioleiomyomatosis . … novant health pre screening

"WebThis phospho-TSC1 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS312 of mouse TSC1. Storage. Aliquot the phospho-TSC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. " - Tsc1 antibody

Tsc1 antibody

WebFeb 5, 2024 · How activated B cells build biosynthetic pathways and organelle structures necessary for subsequent robust antibody secretion is still unclear. The dominant model holds that nascent plasma cells adapt to increased antibody synthesis by activating the unfolded protein response (UPR) under the control of the transcription factor Xbp1. Web"Phospho-Hamartin/TSC1 (Ser511) antibodies" comparison. At Proteintech, we pride ourselves on our antibody quality, customer service and transparency. As such, we are …

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WebProduct Description. Mouse anti Human TSC1 antibody recognizes TSC1, also known as hamartin and tuberous sclerosis 1 protein. TSC1 encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in TSC1 have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript ... WebFeb 16, 2024 · This is a Validated Antibody Database (VAD) review about human TSC1, based on 29 published articles (read how Labome selects the articles), using TSC1 antibody in all methods.It is aimed to help Labome visitors find the most suited TSC1 antibody. Please note the number of articles fluctuates since newly identified citations are added …

WebFeb 25, 2024 · hamartin Antibody (C-8) is an IgG 2b κ mouse monoclonal hamartin antibody (also designated TSC1 antibody or TSC antibody) suitable for the detection of the hamartin protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. hamartin Antibody (C-8) is available as both the non-conjugated anti-hamartin antibody form, as well as … WebApr 14, 2024 · Phase III Abstracts presenting at AACR 2024. Drawing attention to the Phase II data readout, we have cancer vaccine players Moderna and Transgene excited about their personalized therapy.Merck is readily evaluating its flagship product as a combination in high-grade serous ovarian carcinoma, Aadi Biosciences heading towards grabbing a …

WebEach TSC1 Antibody is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. Our TSC1 Antibodies can be used in a variety of model … WebInvitrogen Anti-TSC1 Polyclonal, Catalog # PA5-20130. Tested in Western Blot (WB) applications. This antibody reacts with Human, Mouse samples. Supplied as 100 µg …

WebAnti-TSC1 Antibody has been tested for use in ELISA, Western Blotting, Immunocytochemistry and Immunofluorescence. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 130 kDa in Western Blots of specific cell lysates and tissues.

WebAntibodies that detect TSC1 can be used in several scientific applications, including Western Blot, Immunohistochemistry, Immunocytochemistry, Dot blot and ELISA. These antibodies … novant health pre shift screeningWebTSC1 antibody; see all. Images. Western blot - Anti-TSC-1 antibody (ab200728) All lanes : Anti-TSC-1 antibody (ab200728) Lane 1 : HEK293T whole cell lysate Lane 2 : sp2/0 whole cell lysate Lane 3 : H9C5 whole cell lysate Predicted band … novant health portalWebSep 18, 2024 · The TSC1 and TSC2 genes are connected to multiple syndromes from Tuberous Sclerosis ... The antitumor effects were linearly correlated with vaccinated mouse serum titers of GT198 antibody, ... novant health podiatrist matthews ncWebDetection of human and mouse TSC1 by western blot. Samples: Whole cell lysate (50 µg) from HeLa and mouse NIH3T3 cells prepared using NETN lysis buffer.Antibody: Affinity … how to smoke a turkey breast electric smokerWebSep 1, 2010 · The TSC1 and TSC2 polyclonal antibodies used in this study were purchased from Santa Cruz Biotechnology and used at the manufacturer's recommended dilutions. The anti-T7Tag monoclonal antibody was from Novagen. … how to smoke a tri tip roastWebAug 24, 2012 · The endogenous interaction of TBC1D7 with the TSC1-TSC2 complex was confirmed in reciprocal immunoprecipitations with a panel of six unique antibodies to TSC1 or TSC2, along with an antibody raised against TBC1D7 (Figure 1 B), the specificity of which was confirmed through siRNA-mediated knockdown of TBC1D7 (Figure S1 E).TBC1D7 … how to smoke a turkey breast on a traegerWebNov 10, 2024 · Tsc1 was immunoprecipitated from HEK293 cell lysates using anti-Tsc1 antibody and immunoblotted with indicated antibodies to confirm chaperone, co-chaperone, and client protein interaction. IgG was used as control. FLAG-tagged Hsp90α N-, M-, and C-domains were transiently expressed and immunoprecipitated from HEK293 cells. how to smoke a turkey breast roast