Targeting glutamine metabolism and autophagy

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August undefined, 2024

WebJul 27, 2024 · Metabolic reprogramming and immune escape play a major role in tumorigenesis. Increasing number of studies have shown that reprogramming of glutamine metabolism is a putative determinant of the anti-tumor immune response in the tumor microenvironment (TME). Usually, the predatory uptake of glutamine by tumor cells in … WebBackground: In recent years, metabolic reprogramming has been identified as a hallmark of cancer. Accumulating evidence suggests that glutamine metabolism plays a crucial …

Glutamine, MTOR and autophagy: a multiconnection relationship

WebThe uptake and metabolism of the amino acid glutamine is essential for effector T cell activation. Since the growth and expansion of tumor cells relies on similar anabolic and … Web2 days ago · Cancer cells show increased glutamine uptake and heightened glutaminolysis, as glutamine acts as a substrate for oxidative metabolism and generates more than half of the ATP required by the growing cancer cells [20]. ... Targeting of autophagy and lipid metabolism in cancer stem cells (CSCs). Different autophagy modulators and lipid … magnifying illuminated makeup mirror

Targeting Glutamine Metabolism Ameliorates Autoimmune Hepatitis

WebApr 26, 2024 · Cancer cells metabolize glutamine mostly through glutaminolysis, a metabolic pathway that activates MTORC1. The AMPK-MTORC1 signaling axis is a key regulator of cell growth and proliferation. Our... WebAlthough the role of autophagy as a regulator of tumor radiosensitivity is yet a matter of debate and targeting autophagy is not yet clinically approved as an anticancer … WebApr 27, 2010 · Here, we report a direct link between glutamine (Gln) metabolism and autophagic activity in both transformed and nontransformed human cells. Cells cultured for more than 2 days in Gln-containing medium showed increases in autophagy that were not attributable to nutrient depletion or to inhibition of mammalian target of rapamycin. nyt is this the end of the movies

ASCT2 (SLC1A5)-dependent glutamine uptake is involved in the …

Pharmaceutics Free Full-Text Metabolic Reprogramming in …

WebJul 21, 2024 · Targeting Glutamine Metabolism to Enhance Immunoprevention of EGFR‐Driven Lung Cancer Mofei Huang,1 Donghai Xiong,1 Jing Pan,1 Qi Zhang,1 Shizuko Sei,2 Robert H. Shoemaker,2 Ronald A. Lubet,2 Luis M. Montuenga,3 ,4 ,5 ,6 Yian Wang,1 Barbara S. Slusher,7 ,8 and Ming You1 Mofei Huang 1 Center for Cancer Prevention, … WebApr 3, 2024 · Further insights into metabolic reprogramming by cancer cells are needed to determine if targeting glutamine metabolism could be a useful therapeutic approach. … nytis exploration investor relationsWebConversely, prostate cancer cells with resistance to glutamine depletion show an activation of ATG-mediated macroautophagy/autophagy as a survival strategy to withstand radiation-induced damage. Thus, a combination of targeting glutamine metabolism and … magnifying image on powerpoint

"Webglutamine sufficiency. Our results elucidated a metabolic network by which glutamine metabolism regulates the MTORC1-macroautophagy/autophagy pathway through two independent branches involving glutaminolysis and ASNS-GABA shunt. Abbreviations: αKG: alpha-ketoglutarate; AMPK: AMP-activated protein kinase; ASNS: asparagine " - Targeting glutamine metabolism and autophagy

Targeting glutamine metabolism and autophagy

Targeting glutamine metabolism as an effective means to promote ...

WebGlutaminase can convert glutamine into α-ketoglutarate (α-KG), which participates in the tricarboxylic acid (TCA) cycle to provide energy for cells. 7 Many studies have proved that glutamine metabolism is involved in macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis in cancer cell, thereby ... WebJan 1, 2024 · Autophagy is an essential process that provides glutamine for anaplerosis of the TCA cycle in pancreatic ductal adenocarcinoma. Therefore, targeting glutamine metabolism and autophagy simultaneously to completely inhibit glutamine uptake offers a novel therapeutic approach for treating refractory cancers (Seo et al., 2016).

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WebApr 26, 2024 · Our results elucidated a metabolic network by which glutamine metabolism regulates the MTORC1-macroautophagy/autophagy pathway through two independent … WebMay 19, 2024 · Background: Autoimmune hepatitis (AIH) is mediated by a cascade of T cell-mediated events directed at liver cells and persistent inflammation within the liver can …

Webstrategies may be developed to target PDAC-specific reliance on glutamine metabolism. Autophagy is an essential cellular pathway to provide intracellular energy by … WebJun 27, 2024 · Cancer cells reprogram metabolism to coordinate their rapid growth. They addict on glutamine metabolism for adenosine triphosphate generation and macromolecule biosynthesis. In this study, we report that glutamine deprivation retarded cell growth and induced prosurvival autophagy.

WebCancer cells metabolize glutamine mostly through glutaminolysis, a metabolic pathway that activates MTORC1. The AMPK-MTORC1 signaling axis is a key regulator of cell growth and proliferation. Our recent investigation identified that the connection between glutamine and AMPK is not restricted to glutaminolysis. WebNov 28, 2016 · Autophagy is required to maintain intracellular glutamine levels. ( A) PDAC cells were treated with CQ (10 μM) for 24 h. ( B) Relative glutamine consumption rate of 8988 T cells expressing a...

WebSep 30, 2024 · Analysis of amino acid metabolism showed that L-ASNase caused a certain degree of amino acid deprivation, and the regulation of glutamine metabolism may be the most critical target for L-ASNase. Deprivation of amino acids, including glutamine, was shown to activate autophagy, and glutamine deprivation was a key signal to promote …

WebAUTOPHAGIC PUNCTUM Targeting glutamine metabolism and autophagy: the combination for prostate cancer radiosensitization Anna Mukha a,b,*, Uğur Kahya , and … ny tire staten islandWebDrugs are currently available to target glutamine and related metabolism. However, the use of these compounds has been limited by finding … magnifying infographicWebFeb 5, 2024 · Autophagy. Cancer cell metabolism. 1. Introduction. Glutamine is a conditionally essential amino acid and has the highest concentration in human blood among the amino acids ( Cruzat et al., 2024 ). Generally, mammals do not have to intake glutamine in the diet since it can be synthesized endogenously. magnifying inspection glassesWebSep 5, 2024 · Glutaminase (GLS) is the starting and rate limiting enzyme of glutamine metabolism, and converts glutamine into glutamate, which is decomposed to produce α … magnifyingknowledge.xyzWebSep 5, 2024 · Although the role of autophagy as a regulator of tumor radiosensitivity is yet a matter of debate and targeting autophagy is not yet clinically approved as an anticancer treatment, recent studies showed that the diabetes drug metformin at micromolar concentrations inhibits both glutamine metabolism and autophagy in tumor cells. magnifying insect boxWebDec 10, 2024 · In summary, ASCT2-dependent glutamine uptake and subsequent glutamine metabolism are essential for HNSCC tumorigenesis, and the combination of glutamine uptake inhibitors and cetuximab... nyt is working from home really workingWeb2 days ago · Cancer cells show increased glutamine uptake and heightened glutaminolysis, as glutamine acts as a substrate for oxidative metabolism and generates more than … magnifying keyboard shortcut