List of hepatotoxins
Web17 sep. 1987 · After defining same, please advise where a manufacturer can obtain a list of target organs versus hazardous chemicals. Answer: As stated in our June 29 letter, Appendix C of the standard provides a list of available data sources which can be used to determine the target organ effects of chemicals. Question 3: Define hazards of … Web26 feb. 2012 · Hepatotoxins in Cats. Hepatotoxins are toxic substance that can damage the liver. Some toxins are known for having properties that can bring about liver damage and that almost always lead to liver toxicity. However, an individual cat may be more likely to develop liver toxicity symptoms that are related to a particular drug than another cat ...
List of hepatotoxins
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Webnervous system), hepatotoxins (which affect the liver), and dermatoxins (which affect the skin). However, there have been new studies of effects in other systems, including hematological, kidney, cardiac, reproductive, and gastrointestinal effects. There is evidence that long-term exposure to low levels of microcystins and cylindrospermopsin may WebOther specific hepatotoxins include aflatoxins, toxins derived from amanita mushroom (amanitin), blue-green algae (microcystin), cycad-associated (Sago palm) cycasin, and β …
WebIn vitro models, based on liver cells or tissues, are indispensable in the early preclinical phase of drug development. An important breakthrough in establishing cell models has been the successful high-yield preparation of intact hepatocytes. Web13 mei 2011 · Garlic has the potential ability with a high dose to induce morphological changes in the liver and kidneys, indicating the need to identify a safe dose range for garlic. Prolonged feeding of high levels of raw garlic in rats has resulted in anaemia, weight loss and failure to grow due to the lysis of erythrocytes (38).
Web8 jul. 2014 · A metabolic-idiosyncratic reaction occurs through an indirect metabolite of the offending drug. Unlike intrinsic hepatotoxins, the response rate is variable and can occur within a week or up to one year later. It occurs in a minority of patients taking the drug, and no clinical manifestations of hypersensitivity are noted. WebMicrocystins and nodularins produced by cyanobacteria are potent hepatotoxins and tumor promoters. They are, respectively, cyclic heptapeptides and cyclic pentapeptides containing a characteristic beta-amino acid residue, (2S,3S,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4(E ),6(E)-dieno …
Web21 sep. 2024 · The venom of Australian funnel-web spiders contains δ-hexatoxins (δ-HXTXs) that exert fatal neurotoxic effects in humans by inhibiting inactivation of voltage-gated sodium channels, but their precise ecological role remains unclear. Sequencing of venom-gland transcriptomes from 10 funnel-web species uncovered 22 δ-HXTXs.
WebAll foreign chemicals are capable, at sufficient concentrations, of producing harmful effects on living tissues. From the time of the Industrial Revolution through most of this century, man ignored the spilling of chemicals into the workplace and the environment. Alice Hamilton, the matriarch of industrial medicine and the first woman on the Harvard faculty, … cryptocoryne thwaitesii krindi oyaWebHépatotoxine. Une hépatotoxine (du grec hepato, foie) est une substance chimique toxique ( toxine) qui endommage le foie. L'effet hépatotoxique est provoqué par certaine toxines naturelles comme les microcystines, ou bien être un effet indésirable de certains médicaments, ou encore être dû à l'exposition à certaines substances ... cryptocoryne sunsetWeb23 feb. 2005 · The metabolism of hepatotoxins by cytochrome P-450 enzyme subtypes is a key step of the intoxication; therefore, enzyme inhibitors are shown to minimise the hepatotoxin-associated liver damage. Understanding the function of transcription factors, such as nuclear factor κB (NF-κB) in acute liver injury, may provide some answers as to … cryptocoryne tonkinensis kubotaeWebCimetidine, which inhibits the activity of P450 oxidases with a mixed function, reduces the hepatotoxic effect of paracetamol. Omeprazole works the same way. High doses of … durham newcastle busWebDrugs or toxins that have a pharmacological (type A) hepatotoxicity are those that have predictable dose-response curves (higher concentrations cause more liver damage) and well characterized mechanisms of … durham newcastle trainWeb1 jan. 2013 · This review summarizes current knowledge about the enzymatic basis for the production of the hepatotoxins microcystin and nodularin, the cytotoxin cylindrospermopsin, the neurotoxins anatoxin and saxitoxin, and the dermatotoxin lyngbyatoxin. durham nc wedding venuesWebPhenytoin ( Dilantin) Valproic Acid Carbamazepine Psychotropic Medications Bupropion ( Wellbutrin, Zyban) Tricyclic Antidepressant s Chlorpromazine ( Thorazine) Risperidone ( Risperdal) Selective Serotonin Reuptake Inhibitor s Trazodone Hormonal Medications Tamoxifen Testosterone Miscellaneous Medications Halothane Etretinate Protease … cryptocoryne tonkinensis