WebApr 4, 2024 · data clearly demonstrate the central function of IRF4 in the development of T helper 9 cells and underline the contribution of this T helper cell subset to the pathogenesis of asthma. The 3'-untranslated region (UTR) of IRF4 is a susceptibility locus associated with a modest but highly significant increase in chronic lymphocytic leukaemia risk. WebDec 13, 2024 · 本文由医麦客原创,欢迎分享,转载须授权 2024年12月13日/医麦客 eMedClub/--近日,斯坦福大学医学院研究人员的一项研究显示,一种编程CAR-T细胞的新方法可以延长它们的活性,并增强它们抗癌效力。这一研究是在感染了人类白血病和骨癌细胞的小鼠身上进行的,研究人员希望在未来18个月内开始对...
天使变恶魔!肿瘤相关巨噬细胞利用IRF8促进T2细胞耗竭
WebFeb 11, 2024 · 耗竭T细胞的特征包括抑制性标记物的表达增加,功能的进行性和层次性丧失。. 目前,耗竭已成为癌症患者T细胞功能障碍的公认模式。. 虽然恢复耗竭的CD8+T细胞功能是检查点抑制剂的主要目标,但CD4+T细胞也容易发生耗竭,并且在检查点阻断后的抗肿 … WebJul 18, 2024 · IRF4 hi CD8 + T cells highly express CD25. Healthy donor PBMCs were stimulated with CEF peptides for 18 hours. (A) Mean fluorescence intensity of CD25, CD69, and CD137 in IRF4 neg, IRF4 lo, IRF4 int, and IRF4 hi CD137 + populations. (B) A representative viSNE analysis of CEF-specific CD8 + T cells (gated on CD8 + CD69 + … smaller breed of chicken or duck
攻克T细胞耗竭,BATF——慢性感染和肿瘤免疫治疗的新靶点
WebNov 2, 2024 · 该文章揭示了肿瘤相关巨噬细胞受到irf8调控,产生dc样特点,递呈肿瘤抗原促进cd8+t细胞功能耗竭。 作者首先在MMTV-PyMT (PyMT) 乳腺癌模型中检测单核吞噬细 … WebIrf4 is a critical regulator of many aspects of B- and T-cell differentiation and cell metabolism (Biswas et al., 2012; De Silva, Simonetti, Heise, & Klein, 2012; Eguchi et al., 2011 ). In DCs, Irf4 is highly expressed in the CD4 + subset and in a fraction pDCs ( Tamura et al., 2005 ). In line with this expression pattern, tissue-resident CD4 ... WebJul 19, 2024 · BATF–IRF4 interaction is essential for antitumor responses. A prominent effect of BATF in CD4 + T cells is to recruit IRF to AP-1–IRF composite element (AICE) … smaller burmese cat