WebApr 13, 2024 · The family/class of the large B-cell lymphomas (LBCL) in the 5th edition of the World Health Organization (WHO) classification of haematolymphoid tumors (WHO-HAEM5) features only a few major changes as compared to the 4th edition. In most entities, there are only subtle changes, many of them only representing some minor modifications in … Webirf4 -deleted B cells show differential expression of genes with functions in trafficking To identify genes contributing to the altered migratory properties of IRF4-deficient B cells, we …
Translocations activating IRF4 identify a subtype of germinal …
WebApr 11, 2024 · A notable characteristic of type 2 immunity is that the initiation of the allergic response requires repeated exposures to the allergen. This contrasts with type 1 immunity, where a single infection is sufficient to drive a full-fledged immune response. One possible reason for this difference is that microbial antigens “replicate ... WebDec 10, 2024 · IRF4 is implicated in B cell malignancies, acting both as tumor suppressor and as tumor oncogene in different types of precursors and mature B cell neoplasia. Here, we summarize the complexity of IRF4 functions related to different DNA-binding affinity, multiple IRF4-specific target DNA motif, and interactions with transcriptional partners. cup of salvation passover
Phosphatidylserine-positive extracellular vesicles boost effector …
WebDec 1, 2015 · IRF4 is an unusual component of the activated B cell gene-regulatory network, as it is an obligate controller of opposing cellular states and has been proposed to do this … WebDec 10, 2024 · IRF4 is implicated in B cell malignancies, acting both as tumor suppressor and as tumor oncogene in different types of precursors and mature B cell neoplasia. Here, … WebIrf4 -/-/Irf8 -/-B cells are hyperprolif-erative and fail to induce expression of the Ikaros family factors (Ikaros and Ai- olos) ( Ma et al., 2008). The IRF4 expression is induced by... cup of shrimp calories