Ctgf in ssc
WebSep 10, 2008 · Connective tissue growth factor (CTGF), also know as CCN2, is a small cyteine-rich secreted multi-modular protein, ... Several approaches have been employed for antagonizing, blocking or inhibiting CTGF activity. In the context of SSc-associated lung disease, hepatocyte growth factor has been shown to down-regulate CTGF expression … Web1 The abbreviations used are: TGFβ, tumor growth factor-β; SSc, scleroderma; CTGF, connective tissue growth factor; CMV, …
Ctgf in ssc
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WebApr 1, 2024 · Connective tissue growth factor (CTGF), a member of CCN family, ... Some studies have tried to analyze the relationship between CTGF and SSc deeply in the level of the gene. In the previous study, the polymorphism (G-945C) in the promoter of CTGF gene was tested. It was found that −945G allele was important for the susceptibility to SSc. WebConnective Tissue Growth Factor/CCN2. CTGF is a cysteine-rich 40 kDa matricellular growth factor implicated in angiogenesis, wound healing, and development. Although it is …
WebAlthough the precise molecular mechanisms driving fibrosis remain elusive, TGF-beta and connective tissue growth factor (CTGF), are considered key mediators. CTGF is over-expressed in lesional tissue and enhanced levels in the circulation are an indicator of disease extent and severity. ... In animal models of SSc, neutralization of CTGF with ... WebSep 28, 2014 · Scleroderma (systemic sclerosis, SSc) is a fibrotic disease for which there is no therapy. CCN2 (connective tissue growth factor, CTGF) is a marker and mediator of fibrosis.
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WebMar 3, 2024 · Objective: To examine the mechanism of collagen induction by connective tissue growth factor (CTGF), a profibrotic cytokine overexpressed in the skin of patients with systemic sclerosis (SSc). Methods: Dermal fibroblasts from 7 SSc patients and 7 matched healthy adult donors were stimulated with CTGF in the presence or absence of …
WebFeb 1, 2010 · Objective. Systemic sclerosis (SSc) is a life-threatening autoimmune disease characterized by chronic fibrosis of the skin and internal organs. Connective tissue growth factor (CTGF) is believed to … florist coleraine northern irelandWeb结缔组织生长因子在硬皮病患者皮肤组织上的表达研究.pdf great wolf lodge wi dells day passWebJul 1, 2024 · 1. Introduction. Spermatogenesis is a precisely regulated program that produces sperm from the spermatogonial stem cell (SSC) [].In rodents, spermatogonia can be mainly divided into two subpopulations: the undifferentiated spermatogonia consisting of A-single (A s), A-paired (A pr) and A-aligned (A al) and the differentiating spermatogonia … great wolf lodge wifiWebJul 14, 2013 · Connective Tissue Growth Factor (CTGF), also known as CCN2, is another pleotropic growth factor that has emerged as an important mediator of normal and pathological tissue fibrotic responses [171–174] and has been suggested to play a crucial role in SSc tissue fibrosis. florist collier rowWeb系统性硬化病(systemic sclerosis，SSc)是一种以皮肤增厚和纤维化及胃肠道、肺、心、血管等多个系统受累为特征的自身免疫性疾病。 SSc的病因及发病机制十分复杂，目前认为病因与遗传和环境因素有关，发病机制包括血管病变、免疫系统功能失调、纤维化及3者间的 ... great wolf lodge wi jobsWebConnective tissue growth factor (CTGF) plays a role in the fibrotic process of systemic sclerosis (SSc). Because hypoxia is associated with fibrosis in several profibrogenic conditions, we investigated whether CTGF expression in SSc fibroblasts is regulated by hypoxia. Dermal fibroblasts from patien … florist competitionWebSep 28, 2007 · Pulmonary fibrosis is a frequent complication and a major cause of death in systemic sclerosis (SSc; scleroderma); however, the pathogenesis is unclear and no safe and effective therapy exists (1-3).The pathology of pulmonary fibrosis in SSc includes features of dysregulated and abnormal repair, fibroproliferation, deposition of collagen, … florist colby ks