Cisplatin mechanism of hearing loss

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WebOct 11, 2024 · An additional phenomenon that exacerbates preexisting hearing loss has been identified in patients treated with cisplatin. Those with existing hearing loss at higher frequencies prior to treatment are more likely to experience hearing loss at lower … close drawer menu open drawer menu home. the asha leader; journals. … close drawer menu open drawer menu home. the asha leader; journals. … WebApr 17, 2024 · Late-onset hearing loss is known to occur long after cessation of cisplatin treatment, and these study results suggest that this delayed hearing loss may be related to long-retained cisplatin in the cochlea. Until researchers make significant progress in preventing cisplatin ototoxicity in cancer therapy, it is crucial to continue identifying ...

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WebSep 1, 2024 · Cisplatin for injection can cause ototoxicity, which is cumulative and may be severe. Consider audiometric and vestibular function monitoring. Ototoxicity is manifested by tinnitus, hearing loss in the high frequency range (4,000 to 8,000 Hz) and/or decreased ability to hear normal conversational tones. WebJun 21, 2024 · Hearing loss of grade 1 or higher occurred in 18 of 55 children (33%) in the cisplatin-sodium thiosulfate group, as compared with 29 of 46 (63%) in the cisplatin-alone group, indicating a 48% lower incidence of hearing loss in the cisplatin-sodium thiosulfate group (relative risk, 0.52; 95% confidence interval [CI], 0.33 to 0.81; P=0.002). can hamsters eat ginger

Cisplatin-Induced Ototoxicity: A Concise Review of the Burden ...

WebAug 25, 2024 · Results: The treatment involving chemotherapy with cisplatin caused 41.9% and 47.3% hearing loss in the right and left ear, respectively, with a 11.7-fold higher risk of hearing loss in the right ... WebApr 1, 2008 · He began to exhibit hearing loss after the third cisplatin cycle, with mild (40 dB HL) hearing loss at 8,000 Hz in the left ear and 6,000–8,000 Hz in the right ear. ... Rybak LP, Whitworth CA, Mukherjea D, et al: Mechanisms of cisplatin-induced ototoxicity and prevention. Hear Res 226(1-2):157â 167, 2007. 14. Stelmachowicz PG, Pittman AL ... can hamsters eat fish food

Prevalence and risk factors for cisplatin-induced hearing …

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WebApr 14, 2024 · Hearing aids can protect people from the risk of developing dementia associated with hearing loss, including Alzheimer's disease, according to a new study published in the medical journal The Lancet.. Two previous landmark studies published by the Lancet Commission in 2024 and 2024 showed that hearing loss is the number-one … WebApr 17, 2024 · Late-onset hearing loss is known to occur long after cessation of cisplatin treatment, and these study results suggest that this delayed hearing loss may be … can hamsters eat garlic breadWeb2 days ago · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In particular, the … fit drop an online course

"WebJan 13, 2024 · Cisplatin remains a highly common chemotherapeutic for a number of cancers in both adult and pediatric populations. It is estimated that approximately 50% of chemotherapy regiments include cisplatin [26, 30].The ototoxicity created by cisplatin has a number of concerning consequences including hearing loss, tinnitus, and … " - Cisplatin mechanism of hearing loss

Cisplatin mechanism of hearing loss

Cisplatin-Induced Ototoxicity: A Concise Review of the Burden ...

WebCisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes ototoxicity remains unclear. The purpose of this study was to identify the involvement of receptor-interacting protein kinase (RIP)3-dependent necroptosis in cisplatin-induced ototoxicity in vitro and in vivo. Sprague–Dawley rats (SD, 8 … WebFeb 9, 2016 · INTRODUCTION. Ototoxicity, manifesting as hearing loss, tinnitus, and/or vertigo, is a well-established toxicity associated with a subgroup of antineoplastic therapies that include platinum chemotherapy and radiation or surgery involving the ear and auditory nerve. Supportive care agents, such as aminoglycoside antibiotics and loop diuretics ...

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WebMar 1, 2024 · Although the mechanisms behind cisplatin-associated ototoxicity have not been completely explained, it may mainly involve ROS accumulation in the inner ear, causing a significant increase in lipid peroxidation, consumption of intracochlear antioxidants, and calcium influx, subsequently inducing apoptosis5. WebApr 26, 2024 · Cisplatin primarily affects the high frequencies in both ears and is permanent. The loss of hearing can cause a severe impact on the quality of life, …

WebJul 7, 2024 · Cisplatin is a highly effective treatment for malignant cancers and has become a cornerstone in chemotherapeutic regimens. Unfortunately, its use in the clinic is often … WebThe incidence of ototoxicity induced by cisplatin ranges from 20% to 70%, and it usually manifests as a progressive, bilateral and irreversible hearing loss. Although the …

WebApr 13, 2024 · Spankovich et al. showed a reduced cisplatin-related hearing loss by cold water irrigation in guinea pigs (Spankovich et al., 2016). In an alternative rodent … Web1 hour ago · Fresh bamboo shoots (Chimonobambusa quadrangularis) are subjected to senescence (e.g., lignification and browning) during postharvest storage. This study …

WebMay 2, 2014 · Cisplatin-induced hearing loss is favoured either by preexisting afflictions like hypoalbuminemia, anaemia, renal failure, and noise-induced hearing loss or by risk …

WebJul 3, 2024 · Mechanisms that may underlie cisplatin-induced ototoxicity include excessive ROS, inflammation, cellular uptake of cisplatin, and autophagy, which result in cell death. Preclinical results have … can hamsters eat flourWebAug 1, 2024 · These cisplatin-induced side effects can have a major impact on patient quality of life, including social development problems in pediatric patients that develop hearing loss. Previous... can hamsters eat fliesWebFeb 11, 2024 · Cisplatin is used to treat a wide range of childhood cancers and cisplatin-induced hearing loss (CIHL) is a common and debilitating … can hamsters eat fruit loopsWebMar 26, 2024 · Acquired hearing loss may have multiple causes, but one of the common causes in childhood follows treatment for childhood cancer with cisplatin. For a sound to be perceived, it has to travel through the … fit draft foam top of doorWebMar 15, 2024 · The incidence of ototoxicity induced by cisplatin has been estimated to be 36% of adult patients with cancer and 40%-60% of pediatric patients.2 … fitd rpgWebOct 8, 2012 · The mechanism of accumulation is unknown, but is thought to be by way of carrier-mediated transport in the case of cisplatin, ... Cisplatin-induced hearing loss is related to activation of STAT1. (A) … can hamsters eat grapeWebMar 25, 2024 · Cisplatin is considered one of the most ototoxic pharmacologic agents, typically causing bilateral high frequency sensorineural hearing loss with progression to lower frequencies with continued exposure. can hamsters eat fruit snacks