Cisplatin kidney function
WebJan 12, 2011 · Since its introduction into clinical trials, cisplatin (cis-diammine-dichloro-platinum) has had a major impact in cancer medicine, changing the course of therapeutic management of several tumors, such as those of ovary, testes, and the head and neck. WebJun 18, 2024 · The current use of cisplatin in regimens involving pre and posthydration with careful monitoring of diuresis in the treatment of testicular tumors is associated with renal …
Cisplatin kidney function
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WebFindings: In vivo, after celastrol treatment, cisplatin-induced kidney injury was significantly ameliorated as shown by the improvement of renal function (BUN, serum creatinine, … WebDec 21, 2024 · Myo-inositol, a carbocyclic sugar, is believed to be relevant to renal pathobiology since the kidney is the major site for its catabolism. Its role in acute kidney injury (AKI) has not been fully investigated. Ferroptosis, a unique form of regulated cell death, is involved in various types of renal injuries. The relevance of myo-inositol with …
WebMar 20, 2024 · The reality of cisplatin-induced acute kidney injury (CIA) and its effects on long-term renal function remain unclear. The aim of this study was to investi Impact of … WebFindings: In vivo, after celastrol treatment, cisplatin-induced kidney injury was significantly ameliorated as shown by the improvement of renal function (BUN, serum creatinine, and cystatin C), kidney morphology (PAS staining) and oxidative stress (MDA) and the suppression of renal tubular injury markers of KIM-1 and NGAL.
Cisplatin for injection, USP: single-dose vials containing 50 mg of Cisplatin as white to light yellow lyophilized powder for reconstitution. See more Cisplatin for injection is contraindicated in patients with severe hypersensitivity to Cisplatin [see Warnings and Precautions (5.4)]. See more WebCisplatin for injection has been administered at 75 mg/m. 2 . to 100 mg/m. intravenously per cycle once every 3 to 4 weeks on Day 1. Other doses and combination regimens have been used. 2.4 Advanced Bladder Cancer . Cisplatin for injection has been administered at 50 mg/m. 2 . to 70 mg/m. intravenously per cycle once every 3 to 4 weeks.
WebFeb 1, 2016 · Cisplatin, a commonly used cancer chemotherapeutic, has a dose-limiting side effect of nephrotoxicity. Approximately 30% of patients administered cisplatin suffer from kidney injury, and there are limited treatment options for the treatment of cisplatin-induced kidney injury.
WebSep 15, 2008 · The kidney maintains or autoregulates intraglomerular pressure by modulating the afferent and efferent arterial tone to preserve GFR and urine output. For instance, in patients with volume... churches on indian school rd phoenix azWebTo predict and/or prevent acute kidney injury (AKI) induced by cisplatin, we explored some of the risk factors for AKI. ... 18,20 These previous reports also elucidated the association between the clearance of cationic drugs and the toxicity of cisplatin; however, the function of MATE1/SLC47A1 was unclear in patients with DM. deviantart lipstick kiss marks on faceWebApr 25, 2014 · Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and … churches on green lanesWebFeb 16, 2024 · Common side effects of cisplatin may include: hearing problems; kidney problems; numbness or tingling; nausea, vomiting; or. bone marrow suppression. This is … deviantart light eraserhead88WebJul 5, 2024 · Cisplatin may reduce the ability of the kidneys to excrete the medicines bleomycin and methotrexate and so may increase the risk of side effects from these medicines. Cisplatin may lower the... deviantart log in for maWebFeb 14, 2024 · Nevertheless, 40–50% of patients have impaired renal function that precludes the use of cisplatin. The non-nephrotoxic platinum analogue, carboplatin, has … churches on jekyll islandWebOct 14, 2024 · Cisplatin is an inorganic platinum-based drug that was FDA approved as an anticancer agent in 1978.1It is a standard therapy used to treat many solid organ cancers.2The major mechanism of action of cisplatin involves binding DNA and forming adducts, leading to apoptosis or cell cycle arrest. churches on isle of palms